The Effects of Levetiracetam on Alcohol Consumption in Alcohol-Dependent Subjects: An Open Label Study

Ofra Sarid-Segal Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Joanna Piechniczek-Buczek Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Clifford Knapp Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Maryam Afshar Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Eric Devine Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Laurie Sickles Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Emma Uwodukunda Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Courtney Richambault Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Jillian Koplow Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

Domenic Ciraulo Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA

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Abstract

The aim of this open-label pilot study was to assess the efficacy and safety of the novel anticonvulsant agent, levetiracetam, for the treatment of alcohol dependence. A maximal dose of 2000 mg was administered daily for 10 weeks to alcohol dependent subjects (n = 20). Mean reported ethanol intake declined significantly from 5.3 to 1.7 standard drinks per day. Levetiracetam was well tolerated by most subjects.

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The Effects of Levetiracetam on Alcohol Consumption in Alcohol-Dependent Subjects: An Open Label Study

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