Effect of intrauterine infusion of platelet-rich plasma for women with recurrent implantation failure: a systematic review and meta-analysis

Abstract

This study evaluated the effect of intrauterine perfusion of autologous platelet-rich plasma (PRP) on pregnancy outcomes in women with recurrent implantation failure (RIF). Key biomedical databases were searched to identify relevant clinical trials and observational studies. Outcomes included clinical pregnancy rate, chemical pregnancy rate, implantation rate, live birth rate, and abortion rate. Data was extracted from ten studies (six randomised controlled trials, four cohort studies) involving 1555 patients. Pregnancy outcomes were improved in women treated with PRP compared to controls: clinical pregnancy rate (RR = 1.96, 95% CI [1.67, 2.31], p < 0.00001, I² = 46%), chemical pregnancy rate (RR = 1.79, 95% CI [1.54, 2.08], p < 0.00001, I² = 29%), implantation rate (RR = 1.90, CI [1.50, 2.41], p < 0.00001, I² = 0%), live birth rate (RR = 2.83, CI [1.45, 5.52], p = 0.0007, I² = 83%), abortion rate (RR = 0.40, 95% CI [0.18, 0.90], p = 0.03, I² = 59%). These data imply PRP has potential to improve pregnancy outcomes in women with RIF, suggesting a promising role in assisted reproductive technology.

IMPACT STATEMENT

• What is already known on this subject? Platelet-rich plasma (PRP) is an autologous blood product that contains platelets, various growth factors, and cytokines at concentrations above the normal baseline level. Recent studies have shown that intrauterine infusion of autologous PRP can improve pregnancy outcomes in infertile women.

• What do the results of this study add? This systematic review and meta-analysis of data from ten studies (n = 1555; 775 cases and 780 controls) investigated the effect of intrauterine perfusion of autologous PRP on pregnancy outcomes in women with recurrent implantation failure (RIF). Findings suggest that pregnancy outcomes, including clinical pregnancy rate, chemical pregnancy rate, implantation rate, live birth rate and abortion rate were improved in women treated with PRP compared to controls.

• What are the implications of these findings for clinical practice and/or further research? RIF remains a challenge for researchers, clinicians, and patients. Our study identified PRP as a potential intervention in assisted reproduction. As an autologous blood preparation, PRP eliminates the risk of an immune response and transmission of disease. PRP is low cost and effective and may represent a new approach to the treatment of patients with RIF.

Keywords:

• Platelet rich plasma
• recurrent implantation failure
• systematic review
• meta-analysis

Author contributions

SQW, LM and HYD defined the research problem. SQW designed the search strategy. HYD, LFX and ZJL were responsible for searching and screening literature, and performed statistical analysis of the data. The manuscript was written by HYD and reviewed by SQW and LM. All authors critically reviewed the manuscript for important intellectual content and gave approval of the final version to be published.

Data availability statement

All data generated or analysed during this study are included in published articles.

Additional information

Funding

This study was supported by the Science and Technology Innovation Platform Support Project of Zhongnan Hospital of Wuhan University.