Preoperative clinical characteristics for differentiating malignant transformation from torsion of mature cystic teratoma

Abstract

This retrospective study was conducted in 27 patients with malignant transformation of mature cystic teratoma（MT-MCT）and 125 ovarian teratoma patients with torsion who underwent surgery in the First Affiliated Hospital of Wenzhou Medical University from 2008 to 2019. The incidence of MT-MCT in this study was 0.79%. The 3-year overall survival (OS) rate was 69.6 ± 9.6%. The 3-year progression-free survival (PFS) rate was 58.3 ± 9.6%. Kaplan–Meier survival analysis indicated that patients with squamous cell carcinoma (SCC) had significantly shorter OS compared with non-SCC patients. Older age (OR 1.076, 95% CI 1.041–1.111), higher platelet (PLT) level (OR 1.012, 95% CI 1.005–1.020) and lower neutrophil-to-lymphocyte ratio (NLR) level (OR 0.794, 95% CI 0.647–0.915) were independent predictors of MT-MCT. The area under the curve (AUC) for the combined use of age, PLT count and NLR was 0.921 (95% confidence interval 0.877–0.964; p < 0.001), with a sensitivity of 92.6% and a specificity of 80.8%.

Keywords:

• Diagnosis
• mature cystic teratoma
• malignant transformation
• torsion

Disclosure statement

No potential conflict of interest was reported by the authors.