Vaginal melanoma: a current review

Abstract

Vaginal melanoma is rare, accounting for less than 3% of primary vaginal tumours. It principally affects postmenopausal women, however no risk factors have been identified. Patients frequently present with vaginal bleeding, but the tumour is locally advanced at presentation. Surgery is only the potential cure. The relative merits of radical surgery-vaginectomy and iliac or inguinal lymphadenectomy-versus wide local excision with prompt treatment of recurrences remains uncertain. High dose external radiotherapy and regional chemotherapy trials have been encouraging, although there is no definite survival advantage. Patients should be offered excisional therapy with the opportunity to participate in trials of adjuvant therapy. Prognosis is poor with a five-year survival of 5-21%. Effective screening measures are required enabling earlier diagnosis.