Low pH does not modulate antioxidant status of diphenyl ditelluride but exacerbates Fe (II)-induced lipid peroxidation in liver preparation

Abstract

The relationship of acidosis and lipid peroxidation in liver homogenate was studied and the effect of pH on the antioxidant potential of diphenyl ditelluride is reported. Low pH increased the rate of lipid peroxidation both in the absence and presence of Fe (II), while diphenyl ditelluride (DPDT) inhibited the rate of lipid peroxidation in a concentration-dependent manner at all studied pH values. However, the change in pH did not alter the antioxidant activity of the compound. This study shows acidosis catalyzed oxidative stress in liver homogenate and the antioxidant potential of diphenyl ditelluride.

Keywords::

• pH
• Lipid peroxidation
• diphenyl ditelluride

Acknowledgments

WH is a beneficiary of the TWAS-CNPq doctoral fellowship program. The financial support of TWAS, CAPES SAUX, CNPq, VITAE, and FAPERGS is also acknowledged.

Declaration of interest: All listed authors have contributed significantly to the manuscript and consent to their names on the manuscript. There is no conflict of interest in the conduct and reporting of research (e.g., financial interests in a test or procedure, funding by pharmaceutical companies for drug research).