IMMUNE RESPONSES IN RATS FOLLOWING ORAL IMMUNIZATION WITH ATTENUATED SALMONELLA TYPHIMURIUM EXPRESSING HUMAN SPERM ANTIGEN

Y. Kuang, Y.-C. Yan, A.-W. Gao, Y.-M. Zhai, S.-Y. Miao, L.-F. Wang, S. S. Koide Institute of Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Institute of Developmental Biology, Shandong University, Jinan, China; National Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, China; Center for Biomedical Research, Population COuncil, New York, New York, USACorrespondence [email protected] n

Abstract

The HSD-I gene codes a human sperm membrane protein (hSMP-1) and has been assigned the accession number U12978. The gene is located on human chromosome 9, region p12-p13. When the 1.7-kb cDNA of HSD-I was digested sequentially with EcoRI, BamHI, and HindIII, a 550-bp cDNA fragment was formed, which codes for the extracellular domain. This fragment was cloned into the asd

Keywords

Antifertility Vaccine Immunocontraceptive Oral Immunogen Sperm Membrane Protein

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IMMUNE RESPONSES IN RATS FOLLOWING ORAL IMMUNIZATION WITH ATTENUATED SALMONELLA TYPHIMURIUM EXPRESSING HUMAN SPERM ANTIGEN

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IMMUNE RESPONSES IN RATS FOLLOWING ORAL IMMUNIZATION WITH ATTENUATED SALMONELLA TYPHIMURIUM EXPRESSING HUMAN SPERM ANTIGEN

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