Changes in Nutritional Intake, Body Composition, and Handgrip Strength in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Retrospective Study

Abstract

Patients who undergo autologous hematopoietic stem cell transplantation (autoHSCT) often experience reduced oral intake and wasting. We examined their daily nutritional intake, assessed alterations in body composition and muscle strength, and explored associations between decreased nutritional intake and treatment outcomes. This retrospective study included 64 patients. Their food record charts and parenteral nutrition (PN) prescriptions from medical records were used to assess nutritional intake. Body composition and handgrip strength data were obtained from dietitian records. Patients consumed >75% of their nutritional requirements through an oral diet in 6.7 days, 50–75% in 4.8 days, 25–50% in 5.0 days, and <25% in 3.1 days. The average oral intake was 62% of the requirement and was partially supplemented with PN. Patients experienced a mean decrease in body weight of 2.9 ± 3.0 kg, with 2.3 ± 3.4 kg of lean mass, and a mean reduction in handgrip strength of 3.5 ± 3.6 kg. We found a positive correlation of caloric deficits with weight loss and handgrip strength reduction and negative correlation with time to neutrophil engraftment and duration of hospitalization. This study highlighted a notable reduction in oral nutritional intake following autoHSCT. While caloric deficits might affect outcomes, further investigation is warranted to explore this observation.

Author Contributions

ER initiated the study, participated in its conception and design, analyzed the results, and drafted and finalized the manuscript. KGL designed the study, acquired the data, and drafted the manuscript. MS, IPZ, and SZ participated in the design of the study, and reviewed and edited the manuscript. All the authors have read and approved the final manuscript.

Disclosure Statement

The authors report there are no competing interests to declare.

Funding

This work received no specific grants from any funding agency in the public, commercial, or not-for-profit sectors.

Data Availability Statement

The datasets used and/or analyzed in this study are available from the corresponding author upon reasonable request.