Bilateral periorbital leukemia cutis presenting as suspected cellulitis

ABSTRACT

Many conditions present with periorbital edema and erythema, mimicking preseptal cellulitis. We report the unique case of a patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) acute myeloid leukemia (AML) who presented with periorbital edema and erythema, unresponsive to antibiotics. Histopathology from punch biopsy was consistent with leukemia cutis. The patient responded rapidly to the initiation of enasidenib, a novel targeted inhibitor of mutant IDH2 enzymes. Our case highlights the importance of considering leukemia cutis in patients with a history of leukemia presenting with periorbital edema and erythema.

KEYWORDS:

• Acute myeloid leukemia
• enasidenib
• IDH2 mutation
• leukemia cutis
• periorbital edema

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Consent

Written informed consent was obtained from the patient.