INTERLEUKIN-6 PROMOTER POLYMORPHISM AND LATE-ONSET ALZHEIMER's DISEASE IN THE FINNISH POPULATION

Anne M. Koivisto Department of Neurology, Kuopio University Hospital; Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, FinlandCorrespondence[email protected]

Seppo Helisalmi Department of Neurology, Kuopio University Hospital; Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Finland

Jussi Pihlajamäki Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland

Leena Moilanen Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland

Johanna Kuusisto Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland

Markku Laakso Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland

Mikko Hiltunen Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Finland

Koivisto Keijo Department of Neurology, Central Hospital of South East Bothnia, Seinäjoki, Finland

Tuomo Hänninen Department of Neurology, Kuopio University Hospital; Department of Neurology, University of Kuopio, Finland

Eeva-Liisa Helkala Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland

Kari Kervinen Department of Medicine, Oulu University Hospital, Oulu, Finland

Y. Antero kesäniemi Department of Medicine, Oulu University Hospital, Oulu, Finland

Hilkka Soininen Department of Neurology, Kuopio University Hospital; Department of Neurology, Brain Research Unit, Clinical Research Centre/Mediteknia, University of Kuopio, Finland

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Abstract

Recently, the involvement of the inflammatory response in Alzheimer's disease (AD) has received considerable attention. The gene encoding for interleukin-6 (IL-6) is interesting since IL-6 has been reported not only to be involved in immune functions but also in AD. We investigated whether the IL-6-174 G/C polymorphism is associated with late onset AD (LOAD) in the Finnish subjects. The G allele was over-represented in ApoE4-LOAD patients but remained unimportant in all and in the ApoE E4 carriers. Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations.

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INTERLEUKIN-6 PROMOTER POLYMORPHISM AND LATE-ONSET ALZHEIMER's DISEASE IN THE FINNISH POPULATION

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INTERLEUKIN-6 PROMOTER POLYMORPHISM AND LATE-ONSET ALZHEIMER's DISEASE IN THE FINNISH POPULATION

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