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Abstract
In this communication, anew microencapsulation method is reported toentrap solid drug powder in an aqueous system. A hydrophobically modified, random polyacrylamide derivative was used as astabilizer: with ahydrophilic backbone and hydrophobic side chain, it showed good dispersing and stabilizing effects in the preparation of microcapsules. The preparation of streptomycin microcapsules, using poly(lactide) and poly(caprolactone), showed the successful entrapment of streptomycin powder which is readily soluble in water (solubility larger than 20mg/ml). In addition, a low concentration of stabilizer (0.25%) is used and a short preparation process is also an advantage of the method.