A Candida albicans rough-type mutant with increased cell surface hydrophobicity and a structural defect in the cell wall mannan

Abstract

A Candida albicans rough-type mutant showing increased hydrophobicity of the cell surface was isolated. The mutant cells contained about one-quarter as much mannan as the wild type, and were defective in antigenic factors 1, 4, 5, and 6. Acetolysis fingerprinting demonstrated that the mutant mannan had a structural defect in its carbohydrate skeleton.