Abstract
The activity of Paracoccidioides brasiliensis glucan synthetase was partially inhibited by guanosine 5′-triphosphate, adenosine 3′5′-phosphate and adenosine 5′-triphosphate. This inhibition was more pronounced in the mycelial system than in the yeast one, being higher at 23°C than at 37°C. Addition of ethene diamine tetracetic acid to the incubation mixture inhibited partially the enzymatic activity in mycelial preparations but stimulated it in the yeast system.