Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford

E. A. Pereira Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK

K. A. Muthusamy Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK

N. De Pennington Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK

C. A. Joint Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK

Professor T. Z. Aziz Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UKCorrespondence[email protected]

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

Key words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford

Information for

Open access

Opportunities

Help and information

Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature