Serious and reversible levetiracetam-induced psychiatric symptoms after resection of frontal low-grade glioma: two case histories

Abstract

Levetiracetam may induce serious behavioral disturbances, especially after surgical resection of frontal lobe low-grade glioma. Two patients, treated with levetiracetam, developed serious psychiatric complications postoperatively which completely resolved after switching to valproate. We aim to create awareness for this serious but reversible adverse effect of levetiracetam in this specific patient category.

Keywords:

• Low-grade glioma
• frontal lobe resection
• levetiracetam
• valproate
• psychiatric symptoms
• behavioral changes

Disclosure statement

The authors report no declarations of interest.

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Informed consent was obtained from all individual participants for whom identifying information is included in this article.