Abstract
Introduction: Neurofibromatosis type 1 is an autosomal dominant tumour syndrome with an increased risk of developing central nervous system neoplasms, mostly benign low-grade gliomas involving the optic pathway and the brainstem. High-grade astrocytomas or glioblastoma multiforme (GBM) are rare. Cerebellar GBMs are rarer still, only seven cases NF1 patients have been reported
Case description: We report a case of a cerebellar GBM in a 25-year-old male with NF1 who survived 18 months from the initial diagnosis without surgical debulking but only chemo and radiotherapy.
Conclusion: A literature review found that the best outcomes were achieved in NF1 patients who didn’t undergo gross surgical resection. Possible reasons and future directions are discussed.
Disclosure statement
No potential conflict of interest was reported by the authors.