Choroid plexus and CSF: an updated review

Abstract

In this article, we review the available literature about the functions of the choroid plexus (ChP), including its basic role in cerebrospinal fluid (CSF) secretion, renewal and absorption. We discuss more recently described, lesser-known functions of the ChP, such as its role in circadian rhythm regulation, chemical and immune surveillance and functional implications of ChP disruption, as occurs in neurodegenerative disorders.

Keywords:

• Choroid plexus
• blood-cerebrospinal fluid barrier
• cerebrospinal fluid
• circadian clock
• taste and olfactory signalling
• chemical surveillance
• immune surveillance
• brain disorders
• normal pressure hydrocephalus
• Alzheimer’s disease

Disclosure statement

No potential conflict of interest was reported by the author(s).