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Abstract
In 62 patients undergoing posteroventral pallidotomy (PVP) for the treatment of Parkinson's disease, we have demonstrated significant (p 0.01) elimination of akinetic features and other symptoms during intraoperative stimulation trials in areas anterior to the PVP target (n = 30). Stimulation in anterior pallidal regions frequently resulted in an immediate reversal of akinetic states despite enforced abstinence of medications. The beneficial effects were achieved with as little as 0.25 V at 100 Hz. Stimulation at the PVP target site (n = 32) resulted in insignificant changes (p 0.05).