Recurrent central neurocytoma with marked increase in MIB-1 labelling index

Abstract

Central neurocytomas (CNs) are characterized by an indolent growth and a low recurrence rate. Cell proliferation has been rarely studied in recurrent CNs despite the growing awareness of its prognostic value. We present a CN that recurred rapidly after a prolonged relapse-free interval showing a 4-fold increase of MIB-1 labelling index.

• Central neurocytoma
• Ki-67 (MIB-1) recurrence