The Clinical Impact and Incidence of Periocular Pigmentation Associated with either Latanoprost or Bimatoprost Therapy

Abstract

Purpose: To evaluate the incidence and characteristics of periocular pigmentation with latanoprost versus bimatoprost. Methods: A retrospective, active-controlled comparison of consecutive patients treated with latanoprost or bimatoprost for 12 months evaluating patients to determine the incidence, characteristics, and reversibility of periocular pigmentation. Results: Periocular pigmentation was found in 1% patients treated with latanoprost and 6% patients treated with bimatoprost within 12 months of beginning treatment (p = 0.004). Conclusions: This study suggests that periocular pigmentation may develop after treatment with latanoprost or bimatoprost.

KEYWORDS:

• periocular pigmentation
• latanoprost
• bimatoprost
• incidence
• reversibility