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ORIGINAL ARTICLE

The C523A β₂ Adrenergic Receptor Polymorphism Associates with Markers of Asthma Severity in African Americans

John J. Lima The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USA; Nemours Children's Clinic, Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, Florida, USA

, Pharm.D.,

Janet T. Holbrook The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USA; The Johns Hopkins University, Baltimore, Maryland, USA

, Ph.D., M.P.H.,

Jianwei Wang Nemours Children's Clinic, Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, Florida, USA

, M.D.,

James E. Sylvester Nemours Children's Clinic, Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, Florida, USA

, Ph.D.,

Kathryn V. Blake The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USA; Nemours Children's Clinic, Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, Florida, USA

, Pharm.D.,

Malcolm N. Blumenthal The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USA

, M.D.,

Mario Castro The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USA

, M.D.,

Nicholas Hanania The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USA

, M.D. &

Robert Wise The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USA; The Johns Hopkins University, Baltimore, Maryland, USA

, M.D. show all

Abstract

Our goal was to explore associations between β₂ adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci −1023, −654, −47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively (p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

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The C523A β₂ Adrenergic Receptor Polymorphism Associates with Markers of Asthma Severity in African Americans

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The C523A β2 Adrenergic Receptor Polymorphism Associates with Markers of Asthma Severity in African Americans

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The C523A β₂ Adrenergic Receptor Polymorphism Associates with Markers of Asthma Severity in African Americans