ADA Polymorphisms and Asthma: A Study in the Chinese Han Population

Y. Liu Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China

P. Saccucci Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy

H. Qi Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China

H. C. Wu Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China

F. Zhao Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China

Y. Dai Department of Respiratory Disease, Xijing Hospital, Shaanxi Province, People's Republic of China

N. Bottini Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy

F. Gloria-Bottini Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy

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Abstract

We have studied a sample of 120 asthmatic patients and 116 healthy control subjects from the Chinese Han population. Three polymorphic sites: ADA₁, ADA₂, and ADA₆, within the ADA gene have been examined. The proportion of carriers of *2 allele at locus ADA₁ is drastically reduced in asthmatics as compared to controls. There is an epistatic interaction of ADA₂ on the ADA₁ site characterized by a suppressive effect by the *2 allele of ADA₂ on the protective effect exerted by the *2 allele of ADA₁ site on susceptibility to asthma. Our data suggest the presence of some DNA sequences influencing the susceptibility to asthma are located in the area between ADA₁ and ADA₂ sites.

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ADA Polymorphisms and Asthma: A Study in the Chinese Han Population

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