Pediatric Asthmatic Patients Have Low Serum Levels of Monocyte Chemoattractant Protein-1

Márton Keszei Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary

, M.SC.,

Adrienne Nagy Budai Children's Hospital, Budapest, Hungary

, M.D., PH.D.,

Gergely T. Kozma Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary

, PH.D.,

Károly Radosits Pediatric Pulmonological Ambulance, Siófok, Budapest, Hungary

, M.D.,

Gergely Tölgyesi Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary

, M.SC.,

András Falus Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary; Molecular Immunology Research Group, Hungarian Academy of Sciences, Budapest, Hungary

, D.SC. &

Csaba Szalai Molecular Immunology Research Group, Hungarian Academy of Sciences, Budapest, Hungary; Heim Pál Pediatric Hospital, Budapest, Hungary

, D.SC. show all

Abstract

Serum levels of MCP-1 were measured in children with and without asthma in order to determine a possible correlation between the MCP-1-2518A/G polymorphism, serum levels of MCP-1 and asthma. Two groups of subjects −160 children with asthma and 158 healthy children were screened with a PCR-based genotyping assay. Serum MCP-1 level was measured by ELISA. The -2518G allele occurred at a significantly higher frequency in asthmatic children than in controls. The mean serum MCP-1 level was significantly lower in the asthmatic than in the control children. There was no significant association between the MCP-1 genotypes and the serum MCP-1 levels.

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Pediatric Asthmatic Patients Have Low Serum Levels of Monocyte Chemoattractant Protein-1

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Pediatric Asthmatic Patients Have Low Serum Levels of Monocyte Chemoattractant Protein-1

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