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REVIEW ARTICLE

Tolerability Profiles of Leukotriene Receptor Antagonists and Long-Acting β2-Adrenoceptor Agonists in Combination with Inhaled Corticosteroids for Treatment of Asthma: A Review

, Ph.D., , Ph.D., , Pharm.D., , Ph.D., , M.D., , M.D. & , M.D. show all
Pages 411-422 | Published online: 02 Jul 2009
 

Abstract

Inhaled corticosteroids, long-acting β2-adrenoceptor agonists, and leukotriene receptor antagonists are widely used for treatment of asthma. Inhaled corticosteroids are recommended as first-line therapy, whereas long-acting β2-adrenoceptor agonists and leukotriene receptor antagonists are indicated as add-on therapy in patients not adequately controlled with corticosteroids alone. A number of studies have investigated the efficacy of combinations of these drugs in asthma, but several issues concerning the safety of these treatments are highly debated. This review provides a critical appraisal of the tolerability profiles of long-acting β2-agonists and leukotriene receptor antagonists used in combination with inhaled corticosteroids for the treatment of asthma.

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