Severe Asthma and Its Phenotype

Abstract

The phenotype of severe, or difficult, asthma is poorly understood, but recent studies have been informative. Factors associated with severe asthma include the presence of co-morbidities such as sinusitis, obesity and gastroesophageal reflux, poor adherence with prescribed medical regimens, and a severe underlying disease process. The worst long-term prognosis in severe asthma is associated with the presence of persistent airflow limitation and exacerbations. Individualization of therapy based on phenotype is highly recommended.

Keywords:

• severe asthma
• difficult asthma
• phenotype
• persistent airflow limitation
• exacerbation
• co-morbidity