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Abstract
Objective: To identify early diagnostic profiles such as diagnostic codes and consultation patterns of cancer patients in primary care one year prior to cancer diagnosis.
Design: Total population-based case–control study.
Setting and subjects: 4562 cancer patients and 17,979 controls matched by age, sex, and primary care unit. Data were collected from the Swedish Cancer Register and the Regional Healthcare Database.
Method: We identified cancer patients in the Västra Götaland Region of Sweden diagnosed in 2011 with prostate, breast, colorectal, lung, gynaecological, and skin cancers including malignant melanoma. We studied the symptoms and diagnoses identified by diagnostic codes during a diagnostic interval of 12 months before the cancer diagnosis.
Main outcome measures: Consultation frequency, symptom density by cancer type, prevalence and odds ratios (OR) for the diagnostic codes in the cancer population as a whole.
Results: The diagnostic codes with the highest OR were unspecified lump in breast, neoplasm of uncertain behaviour, and abnormal serum enzyme levels. The codes with the highest prevalence were hyperplasia of prostate, other skin changes and abdominal and pelvic pain. The frequency of diagnostic codes and consultations in primary care rose in tandem 50 days before diagnosis for breast and gynaecological cancer, 60 days for malignant melanoma and skin cancer, 80 days for prostate cancer and 100 days for colorectal and lung cancer.
Conclusion: Eighty-seven percent of patients with the most common cancers consulted a general practitioner (GP) a year before their diagnosis. An increase in consultation frequency and presentation of any symptom should raise the GP’s suspicion of cancer.
Key Points
Knowledge about the prevalence of early symptoms and other clinical signs in cancer patients in primary care remains insufficient.
Eighty-seven percent of the patients with the seven most common cancers consulted a general practitioner 12 months prior to cancer diagnosis.
Both the frequency of consultation and the number of symptoms and diseases expressed in diagnostic codes rose in tandem 50–100 days before the cancer diagnosis.
Unless it is caused by a previously known disease, an increased consultation rate for any symptom should result in a swift investigation or referral from primary care to confirm or exclude cancer.
Ethics
The Regional Ethical Review Board in Gothenburg has approved the study protocol (252-12).
Acknowledgements
The authors thank Erik Holmberg PhD, statistician at Regional Cancer Center West for the extraction of data from the Swedish Cancer Register. We also thank Kristina Narbro, PhD, and Mona-Lis Dalbrekt, Department of Health Care Evaluation, County Council, Västra Götaland Region, for help in the extraction of data from VEGA.
Disclosure statement
The authors declare that they have no competing interests.
Funding information
The study was conducted without external funding. Access to the regional healthcare database VEGA was financed by Regional Cancer Center West, Sahlgrenska University Hospital, Gothenburg, Sweden.