Abstract
Purpose: to study the dose-response relationship in FP 736-03 (48 mg I/ml), a hepatocyte-specific contrast medium for CT of the liver
Material and Methods: A nude-rat model of experimental hepatic metastases was used. CT of the liver was performed before and after i.v. injection of FP 736-03 at 4 different doses: 0.25, 0.5, 1.0 and 2.0 ml/kg b.w. Attenuation in the normal liver parenchyma and in the metastases was measured and plotted as a function of time
Results: the enhancement of the normal liver parenchyma increased in the dose range studied. No increase was found in the metastases; the attenuation here remained constant during the observation period. the maximum enhancement values at doses of 0.25, 0.5, 1.0 and 2.0 ml/kg b.w. were (mean ± SD) 13.5±2.7, 30.1±4.2, 33.2±4.5 and 59.7±13.1 HU respectively