Biokinetics of the Monoclonal Antibodies MOv 18, OV 185 and OV 197 Labelled with ¹²⁵I According to the m-MeATE Method or the Iodogen Method in Nude Mice with Ovarian Cancer Xenografts

Håkan Andersson, Sture Lindegren, Tom Bäck, Lars Jacobsson, Gunilla Leser, György Horvath From the Departments of Gynecological Oncology (H. Andersson, G. Leser, G. Horvath), and Radiation Physics (S. Lindegren, T. Ba ck, L. Jacobsson), Sahlgrenska University Hospital, Gothenburg, Sweden

Abstract

The biodistribution of the radiolabelled monoclonal antibodies MOv18, OV185 and OV197 in nude mice with subcutaneous tumours of the human ovarian cancer cell line OVCAR3 was investigated. The early uptake of MOv18 (1-24 h) and the uptake in relation to tumour size were also studied. The antibodies were labelled with ¹²⁵I according to the Iodogen method or the m-MeATE method, the latter also being suitable for labelling with ²¹¹

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Biokinetics of the Monoclonal Antibodies MOv 18, OV 185 and OV 197 Labelled with ¹²⁵I According to the m-MeATE Method or the Iodogen Method in Nude Mice with Ovarian Cancer Xenografts

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Biokinetics of the Monoclonal Antibodies MOv 18, OV 185 and OV 197 Labelled with 125I According to the m-MeATE Method or the Iodogen Method in Nude Mice with Ovarian Cancer Xenografts

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Biokinetics of the Monoclonal Antibodies MOv 18, OV 185 and OV 197 Labelled with ¹²⁵I According to the m-MeATE Method or the Iodogen Method in Nude Mice with Ovarian Cancer Xenografts