The challenge of Mendelian randomization approach

Abstract

This review deals with methodological problems in current evidence that suggest links between gout and adverse cardiovascular (CV) outcomes and renal disease, and presents a recently adopted approach aimed at overcoming such drawbacks. The review aims to provide more reliable answers regarding the role of uric acid in the pathogenesis and progression of cardiovascular and renal events.

Keywords:

• Mendelian randomization
• hyperuricemia
• cardiovascular risk
• randomized controlled trial

Transparency

Declaration of funding

This review was funded by Fondazione Menarini.

Declaration of financial/other relationships

RP declares sponsorship and speakers bureau from Menarini. Peer reviewers on this manuscript have received an honorarium from CMRO for their review work, but have no other relevant financial relationships to disclose.

Acknowledgments

Editorial assistance for this supplement was provided by Content Ed Net funded by Fondazione Menarini.