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Abstract
Objectives: During the acute phase, patients with Kawasaki disease (KD), an acute systemic vasculitis, demonstrate a drastic increase in serum interleukin‐6 (IL‐6), which parallels the duration of the fever. Recently, IL‐17 has been reported to induce IL‐6 production. The aim of this study was to elucidate the involvement of IL‐17 in the pathogenesis of KD.
Methods: Serum samples were obtained from patients with KD (n=30) and normal controls (n=20), and the concentrations of IL‐17 and IL‐6 measured using enzyme‐linked immunosorbent assay (ELISA).
Results: Compared with the normal controls (2.08±2.14 pg/mL), serum IL‐17 was markedly elevated in patients with acute KD (25.47±5.05 pg/mL); levels gradually decreased in the subacute phase (5.94±2.83 pg/mL). In the acute phase, levels of IL‐6 were 83.52±19.12 pg/L, which correlated well with the serum levels of IL‐17.
Conclusion: These results suggest that IL‐17 may be involved in the development of, or the effects of inflammation in KD.
