Abstract
Objective
In axial spondyloarthritis (axSpA), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS) are recommended for use in treat-to-target (T2T) strategies. However, BASDAI disease states may be a less suitable T2T instrument than ASDAS, since BASDAI contains non-disease activity related items. The objective of our study was to investigate the construct validity of BASDAI and ASDAS disease states.
Method
We performed a single-centre cross-sectional study on BASDAI and ASDAS construct validity in long-term BASDAI T2T-treated axSpA patients. Our hypothesis was that BASDAI is less representative of disease activity than ASDAS owing to the focus on pain and fatigue, and missing an objective item, e.g. C-reactive protein (CRP). This was operationalized using several subhypotheses.
Results
The study included 242 axSpA patients. BASDAI and ASDAS disease states showed a similar relation to Patient Acceptable Symptom State and T2T protocol adherence. The proportions of patients with high BASDAI and ASDAS disease activity fulfilling Central Sensitization Inventory and fibromyalgia syndrome criteria were similar. The correlation with fatigue was moderate for both BASDAI (Spearman’s rho 0.64) and ASDAS (Spearman’s rho 0.54) disease states. A high ASDAS was strongly correlated with increased CRP (relative risk 6.02, 95% CI 3.0–12.09), while this correlation was not seen for BASDAI (relative risk 1.13, 95% CI 0.74–1.74).
Conclusion
Our study showed moderate and comparable construct validity for BASDAI- and ASDAS-based disease activity states, with the expected exception of association with CRP. Therefore, no strong preference can be given for either measure, although the ASDAS seems marginally more valid.
Acknowledgement
We thank A Verkerk for data collection.
Disclosure statement
FvG is a member of the ASAS executive committee. AdB has received research grants (to the institution) from AbbVie, Amgen, Roche, Biogen, Lilly, Novartis, Sanofi, and Gilead. The remaining authors have no potential conflicts of interest to declare.
Author contributions
CM, TB, NdB, LV, and AdB were involved in the study design. CM was involved in the data collection. CM and TB performed the data analyses. All authors were involved in writing, revision, and final approval of the manuscript. CM is the study guarantor. CM contributed to all aspects of the study.
Data availability statement
The data underlying this article will be shared upon reasonable request to the corresponding author according to FAIR principles.
Ethics approval
This study was reviewed by the CMO region Arnhem-Nijmegen and was officially exempted from formal review (CMO number 2021-7431).
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/03009742.2023.2213509