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Original Article

Risk genotypes and haplotypes of the GLUT1 gene for type 2 diabetic nephropathy in the Tunisian population

K Makni Research Unit “Target for Diagnosis and Therapeutic in the Human Pathology”, Center of Biotechnology of Sfax, TunisiaCorrespondence[email protected]

,

F Jarraya Research Unit “Target for Diagnosis and Therapeutic in the Human Pathology”, Center of Biotechnology of Sfax, Tunisia; Department of Nephrology, Hédi Chaker Hospital, Sfax, Tunisia

,

M Rebaï Research Unit “Bioinformatics”, Center of Biotechnology of Sfax, Tunisia

,

F Mnif Department of Endocrinology, Hédi Chaker Hospital, Sfax, Tunisia

,

M Boudawara Laboratory of Analyses, Social National Case of Sfax, Tunisia

,

N Hamza Laboratory of Analyses, Social National Case of Sfax, Tunisia

,

N Rekik Department of Endocrinology, Hédi Chaker Hospital, Sfax, Tunisia

,

M Abid Department of Endocrinology, Hédi Chaker Hospital, Sfax, Tunisia

,

J Hachicha Department of Nephrology, Hédi Chaker Hospital, Sfax, Tunisia

,

C Granier Center of Pharmacology and Biotechnology for Health, CNRS FRE 3009 BIO-RAD CNRS UMR 5094. Faculty of Pharmacy, Montpellier, France

,

A Rebaï Research Unit “Bioinformatics”, Center of Biotechnology of Sfax, Tunisia

,

H Ayadi Research Unit “Target for Diagnosis and Therapeutic in the Human Pathology”, Center of Biotechnology of Sfax, Tunisia

,

K Makni Research Unit “Target for Diagnosis and Therapeutic in the Human Pathology”, Center of Biotechnology of Sfax, TunisiaCorrespondence[email protected]

,

F Jarraya Research Unit “Target for Diagnosis and Therapeutic in the Human Pathology”, Center of Biotechnology of Sfax, Tunisia; Department of Nephrology, Hédi Chaker Hospital, Sfax, Tunisia

,

M Rebaï Research Unit “Bioinformatics”, Center of Biotechnology of Sfax, Tunisia

,

F Mnif Department of Endocrinology, Hédi Chaker Hospital, Sfax, Tunisia

,

M Boudawara Laboratory of Analyses, Social National Case of Sfax, Tunisia

,

N Hamza Laboratory of Analyses, Social National Case of Sfax, Tunisia

,

N Rekik Department of Endocrinology, Hédi Chaker Hospital, Sfax, Tunisia

,

M Abid Department of Endocrinology, Hédi Chaker Hospital, Sfax, Tunisia

,

J Hachicha Department of Nephrology, Hédi Chaker Hospital, Sfax, Tunisia

,

C Granier Center of Pharmacology and Biotechnology for Health, CNRS FRE 3009 BIO-RAD CNRS UMR 5094. Faculty of Pharmacy, Montpellier, France

,

A Rebaï Research Unit “Bioinformatics”, Center of Biotechnology of Sfax, Tunisia

&

H Ayadi Research Unit “Target for Diagnosis and Therapeutic in the Human Pathology”, Center of Biotechnology of Sfax, Tunisia

Abstract

Objective: Diabetic nephropathy (DN) is a long-term complication of both type 1 and type 2 diabetes. Genetic studies on DN have been of little help so far, since several genetic association studies have shown conflicting results. Here we report the findings of a case-control study on five SNPs in the glucose transporter 1 (GLUT1) gene. The study investigated the association of five GLUT1 genotypes and haplotypes with DN.

Research design and methods: All subjects, 126 DN (cases) and 273 type 2 diabetes (controls), were genotyped using the polymerase chain reaction restriction fragment length polymorphism.

Results: The TT and the AA genotypes of the Haell and Enh2 SNP1, increased the risk of DN. The study also identified CGT as the highest risk haplotype (4.4-fold) followed by CAT with an increased risk of DN of 2.6-fold.

Conclusions: The GLUT1 gene confers susceptibility to DN in type 2 diabetes patients in the Tunisian population.

Keywords

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