Differential Risk of Hypertension Among Lean and Nonlean Rural Subjects in Relation to Decadal Changes in Anthropometry

ABSTRACT

Objective: Assessing risk of hypertension in relation to decadal changes in anthropometry among cohort of young rural Indian men.

Methods: Subjects (n = 140) were measured in 2005 and 2015 for blood pressure, body mass index (BMI), body fat (BF), waist circumference (WC), waist-to-hip ratio (WHR), and additionally for visceral fat (VF) at follow-up.

Results: Decadal changes showed significant (p < 0.001) increase in mean anthropometric measures and in prevalence of overall obesity (BMI ≥25 kg/m²) from 3.6% to 37.1%; adiposity (BF ≥25%) from 5.1% to 40.9%; and central obesity (WHR ≥0.9) from 0.7% to 24.3%. Prevalence of hypertension increased (20.7% to 27.1%) but was not statistically significant. VF correlated significantly (p < 0.001) with decadal changes (Δ) in BMI, BF, WC, and WHR, and the correlations were stronger (r = 0.90, 0.78, 0.84, and 0.56, respectively) for lean (baseline BMI < median) subjects than nonlean (baseline BMI ≥median) subjects (r = 0.68, 0.40, 0.61, and 0.43, respectively). Risk of hypertension was significant (odds ratio [OR] = 11.0, 95% confidence interval [CI]: 2.8–42.8) for subjects with higher ΔBMI (≥4.7 kg/m²) compared with those with lower ΔBMI (<4.7 kg/m²) among lean but was not significant among nonlean subjects. This was also true for change in other adiposity indicators, indicating greater vulnerability of lean subjects. Further, among lean subjects, ORs reduced considerably after adjusting for VF, whereas among nonlean subjects ORs continued to remain nonsignificant but showing independent significance for VF.

Conclusions: For similar level of change in adiposity indicators, lean subjects were at greater risk of hypertension than nonlean subjects, probably due to higher VF deposition.

KEYWORDS:

• Decadal change
• hypertension
• lean
• visceral fat

Acknowledgments

The authors are grateful to the director, Society for Initiatives in Nutrition and Development, Pune, and to the director, School of Health Science, Savitribai Phule Pune University, Pune, for providing necessary facilities for conducting this research. The authors are also grateful to the Indian Council of Medical Research, New Delhi, for awarding senior research fellowship to S.D.J.

The results reported in this article have been presented partially at the 48th annual national conference of the Nutrition Society of India, India, during 5–6 December 2016.