A Systematic Review on Drug Interactions in Oncology

Abstract

Objectives: To systematically review drug interactions in oncology. Methods: We searched PubMed for eligible articles and online databases abstracts of major oncology meetings from 2002 to 2005. Results: One study reported on the frequency of drug interactions. Interactions between chemotherapy and nonchemotherapy agents have been reported mostly in small clinical trials and case series. Interactions between chemotherapic agents have been reported mostly in Phase I studies. Few studies described fatal outcomes of drug interactions in cancer patients. Conclusion: Drug interactions comprise an important issue in oncology, but very limited data exist on their frequency and clinical consequences.

Keywords:

• Adverse effects
• Drug interactions
• Drug therapy
• Combination
• Neoplasms