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Abstract
Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.
| ABBREVIATIONS | ||
| FFPE | = | Formalin fixed parafin embedded |
| GSH | = | glutathione |
| MDR | = | Multidrug resistance |
| MRP1 | = | Multidrug Resistance-associated Protein-1 |
| ABBREVIATIONS | ||
| FFPE | = | Formalin fixed parafin embedded |
| GSH | = | glutathione |
| MDR | = | Multidrug resistance |
| MRP1 | = | Multidrug Resistance-associated Protein-1 |