YY1 Over-Expression in Human Brain Gliomas and Meningiomas Correlates with TGF-β1, IGF-1 and FGF-2 mRNA Levels

Stavroula Baritaki Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California, USA

Anthoula M. Chatzinikola Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece

Antonios F. Vakis Department of Neurosurgery, University Hospital of Crete, Heraklion, Crete, Greece

Nikolaos Soulitzis Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece

Dimitris A. Karabetsos Department of Neurosurgery, University Hospital of Crete, Heraklion, Crete, Greece

Ioannis Neonakis Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece

Benjamin Bonavida Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California, USA

Demetrios A. Spandidos Department of Clinical Virology, Medical School, University of Crete, Heraklion, Crete, Greece

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Abstract

In this study we examined by QRT-PCR the mRNA expression of TGF-β 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors. Our findings introduce YY1, for the first time, as a novel gene implicated in brain gliomatogenesis and meningioma establishment. We present a positive correlation between the autocrine expression of YY1 and TGF-β 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. We suggest that mRNA profiling of the above genes in the early stages of disease development could be useful for prognostic purposes, and these genes can be considered as potential targets for therapeutic approaches against brain tumors.

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YY1 Over-Expression in Human Brain Gliomas and Meningiomas Correlates with TGF-β1, IGF-1 and FGF-2 mRNA Levels

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YY1 Over-Expression in Human Brain Gliomas and Meningiomas Correlates with TGF-β1, IGF-1 and FGF-2 mRNA Levels

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