First principle-based models in plant suspension cell cultures: a review

Abstract

In this work, the development and application of published models for describing the behavior of plant cell cultures is reviewed. The structure of each type of model is analyzed and the new tendencies for the modeling of biotechnological processes that can be applied in plant cell cultures are presented. This review is a tool for clarifying the main features that characterize each type of model in the field of plant cell cultures and can be used as a support on the selection of the more suitable model type, taking into account the purpose of specific research.

Keywords:

• Unstructured models
• structured-stoichiometric models
• structured-mechanistic models
• hybrid stoichiometric-kinetic models
• segregated models
• MFA
• FBA

Acknowledgements

The authors thank the Universidad Nacional de Colombia, Medellin campus. Adriana Villegas is grateful to the Universidad Cooperativa de Colombia for the Sustainability Strategy.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

The authors thank the Universidad de Antioquia for the financial support provided to the development of this work through the CODI grant MDC11-1-08.