https://orcid.org/0000-0002-2868-4497
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Abstract
Aim
This study aimed to identify the prevalence and distribution of high-risk human papillomavirus (HR-HPV) types among Kazakhstani women with abnormal cervical cytology.
Methods
A cross-sectional study was performed from May 2019 to June 2020. Cervical samples were collected from women in the different regions of Kazakhstan.
Results
A total of 316 patients’ samples were analysed for HR-HPV using real-time multiplex PCR. Cervical cytology abnormalities were reported according to the Bethesda classification. HPV detection by cytology showed a statistically significant association with HPV status and the number of HPV infection types (p < .05). Among women with abnormal cervical cytology, 62.4% were positive for HPV infection of those 79.4% had low-grade squamous intraepithelial lesions (LSIL), and 20.6% had high-grade squamous intraepithelial lesions (HSIL). Among patients with LSIL, 77.4% had HPV16 and 58.8% were infected with HPV18. Among patients with HSIL, 41.2% had HPV18 and 22.6% – HPV16.
Conclusions
There is a high prevalence of HR-HPV types among Kazakhstani women with abnormal cervical cytology. The most identified types were HPV16, 18, 31, 33 and 52. There is an emergency need to implement an HPV vaccination program to prevent cervical lesion development.
Acknowledgements
The authors acknowledge the Nazarbayev University School of Medicine for the support that enabled the completion of this study.
Author contributions
GA and AA were involved in creating the study protocol; AM and YI were involved in the process of the samples collection. TI, AB and AA performed PCR sample analysis; AI, TI, AB, AG and NM performed statistical analysis and data interpretation; GA, AM, YI and AA involved in preliminary data design and assessment, and literature review. GA, AB and TI drafted the manuscript. AI and GA provided a critical revision and regular feedback of the manuscript. All authors contributed to the refinement of the study protocol. All authors have read and approved the final manuscript.
Ethical approval
The study was approved by the Institutional Research Ethics Committee of the Nazarbayev University on 23 April 2019 (IREC number: 146/4042019).
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The study questionnaires and raw data are available from the project PI via email: [email protected]