Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up

Abstract

Background

This is the first study to examine the clinical utility of measuring plasma secretoneurin (SN) levels in patients with heart failure with reduced ejection fraction (HFrEF), as a predictor of unplanned hospitalization, and all-cause mortality independently, and as a composite endpoint at one-year follow-up.

Methods

The study group includes 124 caucasian patients in New York Heart Association (NYHA) classes II to IV. Plasma SN concentrations were statistically analyzed in relation to sex, age, BMI, etiology of HFrEF, pharmacotherapy, clinical, laboratory and echocardiographic parameters. Samples were collected within 24 h of admission to the hospital.

Key results

In the 12-month follow-up, high SN levels were noted for all three endpoints.

Conclusions

SN positively correlates with HF severity measured by NYHA classes and proves to be a useful prognostic parameter in predicting unplanned hospitalizations and all-cause mortality among patients with HFrEF. Patients with high SN levels may benefit from systematic follow-up and may be candidates for more aggressive treatment.

Keywords:

• Secretoneurin
• heart failure
• HFrEF
• biomarker
• cardiovascular system

Author contributions

Łukasz Wołowiec- Conceptualization, Formal analysis, Methodology, Writing - Original Draft, Project administration, Supervision; Daniel Rogowicz - Original Draft, Project administration, Data Curation; Jacek Budzyński- Formal analysis, Writing - Original Draft, Visualization; Joanna Banach- Writing - Original Draft Project administration, Data Curation; Anna Wołowiec- Writing - Original Draft, Resources, Data Curation; Mariusz Kozakiewicz- Writing - Original Draft, Resources, Data Curation; Maciej Bieliński- Writing - Original Draft, Resources, Data Curation; Albert Jaśniak- Writing - Original Draft, Visualization; Joanna Osiak- Writing - Original Draft, Resources, Data Curation; Grzegorz Grześk- Conceptualization, Methodology, Writing - Original Draft, Supervision.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

All data used to support the finding of this study are available from the corresponding author upon request.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.