https://orcid.org/0000-0002-7843-8876
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Abstract
Background
Despite the widespread administration of coronavirus disease 2019 (COVID-19) vaccines, the impact on patients with asymptomatic to mild illness remains unclear. Here, we aimed to assess the efficacy of various vaccine doses and types on the duration of isolation duration and discharge rates, the viral shedding duration, and negative rates in asymptomatic to mild COVID-19 patients.
Methods
We included adult patients at the Fangcang isolation centres in Pazhou or Yongning between November and December 2022. We analysed data on basic demographics, admission details, laboratory indicators and vaccination information.
Results
A total of 6560 infected patients were included (3584 from Pazhou and 2976 from Yongning). Of these, 90.6% received inactivated vaccines, 3.66% received recombinant SARS-CoV-2 spike protein subunit vaccines and 0.91% received adenovirus vaccines. Among the 6173 vaccinated individuals, 71.9% received a booster dose. By day 9, the isolation rate reached 50% among vaccinated patients. On day 7.5, the positive rate among vaccinated individuals reached 50%.
Conclusions
Full vaccination was effective, with heterologous vaccines showing greater efficacy than inactivated vaccines alone. However, there was no significant difference in the vaccine protective effect 12 months after vaccination.
Acknowledgements
The authors would like to express their sincere appreciation and gratitude to the staff members and involved patients of the First Affiliate Hospital of Guangzhou Medical University, Fangcang isolation centre in Pazhou and Yongning for their tremendous assistance and cooperation in the study.
Author contributions
Conceptualization, J.M. and Y.D.X.; methodology, J.M. and X.T.K.; software, X.T.K.; validation, all authors; formal analysis, X.T.K.; investigation, all authors; resources, Y.D.X., W.Q.H. and Z.J.L.; data curation, Y.D.X. and X.T.K.; writing – original draft preparation, X.T.K.; writing – review and editing, all authors; visualization, X.T.K.; supervision, J.M. and Y.D.X.; project administration, J.M., Y.D.X., W.Q.H. and Z.J.L.; funding acquisition, J.M. and Y.D.X. All authors have read and agreed to the published version of the manuscript.
Ethical approval
The First Affiliate Hospital of Guangzhou Medical University Research Ethics Committee reviewed the manuscript and consent for publication (approval number ES-2023-116-01). Participants provided their informed consent.
Consent form
Written informed consent was obtained from all patients for publication.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.