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Abstract
Atherosclerosis and its clinical manifestations are the leading cause of death in Western countries. Atherosclerosis is a multifactorial disease characterized by endothelial dysfunction, smooth muscle cell (SMC) proliferation and migration, inflammation, lipid and matrix accumulation and thrombus formation. Multiple genetic and environmental features and interactions between these factors influence the disease process. To understand fundamental pathobiological mechanisms in atherogenesis and to develop and target new therapies, information on genetic factors (atherogenetics), gene expression patterns (atherogenomics) and protein expression patterns (atheroproteomics) are needed. This review will summarize current knowledge in these areas of atherosclerosis research with a special emphasis on microarray technology.
| Abbreviations | ||
| ApoE | = | apolipoprotein E |
| CETP | = | cholesteryl ester transfer protein |
| CRP | = | C‐reactive protein |
| CSF | = | colony stimulating factor |
| CVD | = | cardio vascular diseases |
| HMG‐CoA | = | 3‐hydroxy‐3‐methylglutaryl‐Coenxyme A |
| HPBM | = | human peripheral blood monocytes |
| IL | = | interleukin |
| LDL | = | low density lipoprotein |
| LMD | = | laser microdissection |
| LPS | = | lipopolysaccharide |
| MCP | = | mococyte chemotactic protein |
| MMP | = | matrix metalloproteinase |
| PAI | = | plasminogen activator inhibitor |
| PMA | = | phorbol 13‐myristate 12‐acetate |
| SMC | = | smooth muscle cells |
| SNP | = | single nucleotide polymorphism |
| SOD | = | superoxide dismutase |
| TNF | = | tumor necrosis factor |
| Abbreviations | ||
| ApoE | = | apolipoprotein E |
| CETP | = | cholesteryl ester transfer protein |
| CRP | = | C‐reactive protein |
| CSF | = | colony stimulating factor |
| CVD | = | cardio vascular diseases |
| HMG‐CoA | = | 3‐hydroxy‐3‐methylglutaryl‐Coenxyme A |
| HPBM | = | human peripheral blood monocytes |
| IL | = | interleukin |
| LDL | = | low density lipoprotein |
| LMD | = | laser microdissection |
| LPS | = | lipopolysaccharide |
| MCP | = | mococyte chemotactic protein |
| MMP | = | matrix metalloproteinase |
| PAI | = | plasminogen activator inhibitor |
| PMA | = | phorbol 13‐myristate 12‐acetate |
| SMC | = | smooth muscle cells |
| SNP | = | single nucleotide polymorphism |
| SOD | = | superoxide dismutase |
| TNF | = | tumor necrosis factor |
Acknowledgements
This study has been supported by the Finnish Academy, the Finnish Foundation for Cardiovascular Research, the Finnish Cultural Foundation, the Aarne Koskelo Foundation, the Paavo Nurmi Foundation, Bio‐Molecular Therapeutics, Vienna, the Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences and the European Vascular Genomics Network (EVGN LSHM‐CT‐2003‐503254).