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Abstract
Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions both in the tissue destruction and immune responses related to periodontal inflammation. The expression and activity of MMPs in non‐inflamed periodontium is low but is drastically enhanced to pathologically elevated levels due to the dental plaque and infection‐induced periodontal inflammation. Soft and hard tissue destruction during periodontitis and peri‐implantitis are thought to reflect a cascade of events involving bacterial virulence factors/enzymes, pro‐inflammatory cytokines, reactive oxygen species and MMPs. However, recent studies suggest that MMPs can also exert anti‐inflammatory effects in defence of the host by processing anti‐inflammatory cytokines and chemokines, as well as by regulating apoptotic and immune responses. MMP‐inhibitor (MMPI)‐drugs, such as doxycycline, can be used as adjunctive medication to augment both the scaling and root planing‐treatment of periodontitis locally and to reduce inflammation systematically. Furthermore, MMPs present in oral fluids (gingival crevicular fluid (GCF), peri‐implant sulcular fluid (PISF), mouth‐rinses and saliva) can be utilized to develop new non‐invasive, chair/bed‐side, point‐of‐care diagnostics for periodontitis and dental peri‐implantitis.
| Abbreviations | ||
| AP‐1 | = | activating protein‐1 |
| (CA)n | = | microsatellite containing tandem repeats of deoxy (cytidine, adenine) sequences |
| ECM | = | extracellular matrix |
| EDTA | = | ethylenediamine tetraacetic acid |
| FDA | = | Food and Drug Administration |
| IFMA | = | time‐resolved immunofluorometric assay |
| LPS | = | lipopolysaccharide |
| RUNT | = | RUNT‐domain containing transcription factor |
| RUNX | = | RUNX‐related protein containing transcription factor |
| TGF | = | transforming growth factor |
| TPA | = | tetradecanoylphorbol acetate |
| Abbreviations | ||
| AP‐1 | = | activating protein‐1 |
| (CA)n | = | microsatellite containing tandem repeats of deoxy (cytidine, adenine) sequences |
| ECM | = | extracellular matrix |
| EDTA | = | ethylenediamine tetraacetic acid |
| FDA | = | Food and Drug Administration |
| IFMA | = | time‐resolved immunofluorometric assay |
| LPS | = | lipopolysaccharide |
| RUNT | = | RUNT‐domain containing transcription factor |
| RUNX | = | RUNX‐related protein containing transcription factor |
| TGF | = | transforming growth factor |
| TPA | = | tetradecanoylphorbol acetate |
Acknowledgements
The research in our laboratories has been supported grants from the Academy of Finland and the HUCH‐EVO (TYH 5306, TYH 6104 and TI 020Y0002) Foundation.