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Abstract
The molecular circadian clock entrains biological rhythms to a 24‐hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecular clock in the pathophysiology of cardiovascular and metabolic disease.
Yet taught by time, my heart has learned to glow for other's good and melt at other's woe.
Homer.
| Abbreviations | ||
| ACTH | = | adrenocorticotrophic hormone |
| Epi | = | epinephrine |
| GR | = | glucocorticoid receptor |
| HPA | = | hypothalamic‐pituitary‐adrenal |
| KO | = | knockout |
| MAP | = | mean arterial pressure |
| NO | = | nitric oxide |
| NSAID | = | non‐steroidal anti‐inflammatory drug |
| PAI | = | plasminogen activator inhibitor |
| PAS | = | Per Arnt Sim |
| SUMO | = | small ubiquitin‐like modifier |
| tPA | = | tissue plasminogen activator |
| Abbreviations | ||
| ACTH | = | adrenocorticotrophic hormone |
| Epi | = | epinephrine |
| GR | = | glucocorticoid receptor |
| HPA | = | hypothalamic‐pituitary‐adrenal |
| KO | = | knockout |
| MAP | = | mean arterial pressure |
| NO | = | nitric oxide |
| NSAID | = | non‐steroidal anti‐inflammatory drug |
| PAI | = | plasminogen activator inhibitor |
| PAS | = | Per Arnt Sim |
| SUMO | = | small ubiquitin‐like modifier |
| tPA | = | tissue plasminogen activator |