Mitochondrial involvement in psychiatric disorders
2008, Vol. 40, No. 4
,
Pages 281-295
(doi:10.1080/07853890801923753)
Ling Shao, Maureen V. Martin, Stanley J. Watson, Alan Schatzberg, Huda Akil, Richard M. Myers, Edward G. Jones, William E. Bunney and Marquis P. Vawter
Department of Psychiatry & Human Behavior, University of California, Irvine, Irvine CA, USA
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
Department of Psychiatry, Stanford University, Palo Alto, CA, USA
Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
Neuroscience Center, University of California, Davis, Davis, CA, USA
Recent findings of mitochondrial abnormalities in brains from subjects with neurological disorders have led to a renewed search for mitochondrial abnormalities in psychiatric disorders. A growing body of evidence suggests that there is mitochondrial dysfunction in schizophrenia, bipolar disorder, and major depressive disorder, including evidence from electron microscopy, imaging, gene expression, genotyping, and sequencing studies. Specific evidence of dysfunction such as increased common deletion and decreased gene expression in mitochondria in psychiatric illnesses suggests that direct examination of mitochondrial DNA from postmortem brain cells may provide further details of mitochondrial alterations in psychiatric disorders.
