Atherosclerotic plaque development and instability: A dual role for VEGF

Pieter W. Holm Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Riemer H. J. A. Slart Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Clark J. Zeebregts Department of Surgery (Division of Vascular Surgery), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Jan L. Hillebrands Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

René A. Tio Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsCorrespondence[email protected]

Abstract

Vascular endothelial growth factor (VEGF), a potent growth factor for endothelial cells and inducer of angiogenesis, is important for endothelial integrity and thus for vascular function. On the other hand, VEGF may enhance the pathophysiologic mechanism of plaque formation and plaque destabilization. In this review we discuss the data available so far for VEGF as angiogenic and/or inflammatory cytokine in the vulnerable atherosclerotic plaque.

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Atherosclerotic plaque development and instability: A dual role for VEGF

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Atherosclerotic plaque development and instability: A dual role for VEGF

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