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Abstract
The serotonintransporter (SERT) reuptakes serotonin at the synapse and is thus involved in the termination of its action. SERT is potentially relevant for the pathophysiology of several psychiatric disorders and thought to be the site of therapeutic action for many antidepressants. The chromosomal localization and structure of the SERT gene has been established. Furthermore, DNA sequence variation of possible functional relevance has been described in the promoter region and in the second intron. This knowledge makes it possible to investigate the role of the SERT gene in psychiatric diseases, personality disorders, interaction with the environment, treatment response and side effects. The article reviews investigations of the possible role of variants in the SERT gene, especially in relation to affective disorders.