Ontogeny of Tumor-associated CD4+CD25+Foxp3+ T-regulatory Cells

ABSTRACT

The critical contribution of CD4+CD25+Foxp3+ T-regulatory cells (Treg) to immune suppression in the tumor microenvironment is well-established. Whereas the mechanisms that drive the generation and accumulation of Treg in tumors have been an active area of study, the information on their origin and population dynamics remains limited. In this review, we discuss the ontogeny of tumor-associated Treg in light of the recently identified lineage markers.

KEYWORDS:

• Immune therapy
• ontogeny
• peripheral Treg
• thymic Treg
• T-regulatory cell
• tumor

Declaration of interest

The authors declare no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This work was supported by the National Institutes of Health Grant R01 CA100656 (to N.K.E.).