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International Reviews of Immunology Volume 40, 2021 - Issue 1-2: Biology of Coronavirus Disease
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Review

Pathogenesis guided therapeutic management of COVID-19: an immunological perspective

Ashutosh Kumara Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;b Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1589-9568View further author information
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Pranav Prasoona Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;c Pittsburgh Center for Pain Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USAORCID Iconhttps://orcid.org/0000-0002-5035-3619View further author information
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Prakash S. Sekhawata Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;d Department of Hematology, Nil RatanSircar Medical College and Hospital (NRSMCH), Kolkata, IndiaORCID Iconhttps://orcid.org/0000-0002-8164-3045View further author information
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Vikas Pareeka Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;e National Brain Research Center, Manesar, Haryana, IndiaORCID Iconhttps://orcid.org/0000-0001-8985-4982View further author information
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Muneeb A. Faiqa Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;f NYU Robert I Grossman School of Medicine, New York University (NYU) Langone Health Center, New York, New York, USAORCID Iconhttps://orcid.org/0000-0002-1430-3139View further author information
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Chiman Kumaria Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;g Department of Anatomy, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0002-9116-8380View further author information
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Ravi K. Narayana Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;b Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, IndiaORCID Iconhttps://orcid.org/0000-0003-2510-6744View further author information
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Maheswari Kulandhasamya Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;h Department of Biochemistry, Maulana Azad Medical College (MAMC), New Delhi, IndiaORCID Iconhttps://orcid.org/0000-0002-6769-2596View further author information
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Kamla Kanta Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India;i Department of Microbiology, All India Institute of Medical Sciences (AIIMS), Bathinda, IndiaORCID Iconhttps://orcid.org/0000-0002-8966-6268View further author information
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Pages 54-71 | Received 21 Jun 2020, Accepted 17 Oct 2020, Published online: 28 Oct 2020
 
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Abstract

Lack of standardized therapeutic approaches is arguably the significant contributor to the high burden of mortality observed in the ongoing pandemic of the Coronavirus disease, 2019 (COVID-19). Evidence is accumulating on SARS-CoV-2 specific immune cell dysregulation and consequent tissue injury in COVID-19. Currently, no definite drugs or vaccines are available against the disease; however initial results of the ongoing clinical trials have raised some hope. In this article, taking insights from the emerging empirical evidence about host-virus interactions, we deliberate upon plausible pathogenic mechanisms and suitable therapeutic approaches for COVID-19.

Disclosure statement

All the authors declare “No Conflict of Interest.”

Author contributions

A.K. wrote the first draft. P.P., P.S.S., V.P., M.A.F., C.K., R.K.N., M.K., and K.K. revised the draft. P.P. and A.K. prepared tables and figures.

Additional information

Funding

There was no dedicated funding for this project.

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