Gold Nanoparticle as an Alternative Tool for Urine Microalbumin Test: The First World Report

Abstract

Urine microalbuminuria is a common indicator for occult preclinical nephropathy. At present, urine microalbumin test is routinely performed by clinical chemistry test. Here, the authors used the advanced nanomedicine technique for modification of the urine microalbumin test. Materials and methods. The preparation of gold nanoparticle solution in this study was according to the standard method reported by Frenkel et al. The author performed an experiment on both microalbumin positive and negative urine samples. First, the mixture between equal amount (500 microliter) of gold nanoparticle solution and urine sample was prepared. Results. The microalbumin-positive mixture becomes purple, while the pregnancy-negative mixture becomes gray. Conclusion. This application can help the diagnosis of microalbumin and can be the alternative way for this urine microalbumin test. This is the first world report on this application.

Keywords:

• urine
• microalbumin
• gold
• nanomedicine