Predictive role of endothelin in left ventricular remodeling of chronic kidney disease

Abstract

Background: In chronic kidney disease (CKD), endothelin-1 (ET-1) always increases and there are changes in cardiac ultrasonography. In the present study, we aimed at investigating the role of serum ET-1 in predicting cardiac complications in patients with CKD.

Methods: The level of serum ET-1 was measured by enzyme-linked immunosorbent assay (ELISA) and cardiac ultrasonography was performed in enrolled patients. Indexes of heart failure, such as left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter, were measured in patients with CKD.

Results: In the present study, we found that the level of serum ET-1 was significantly correlated with left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter (p < .001) in non-dialysis patients with CKD.

Conclusions: The results of the present study indicated that the level of serum ET-1 is closely related to the cardiac complications of CKD and is a useful predictor of cardiac complication.

Keywords:

• Chronic kidney disease
• ventricular remodeling
• endothelin-1
• cardiac complication
• non-dialysis

Limitations

This study had some limitations, including the small sample size and the short time.

Acknowledgements

All authors express their appreciation to the enrolled patients.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by Shandong Province Outstanding Young Scientist Research Award Fund Project, No. [BS2013YY042]. Natural Science Foundation of Shandong Province, No. [ZR2013HM106].