![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Background
The purpose of this study was to explore the risk factors for renal nonrecovery among elderly and nonelderly patients with acute kidney injury (AKI) in critically ill patients.
Methods
A multicenter retrospective cohort of 583 critically ill patients with AKI was examined. We found the best cutoff value for predicting renal recovery by age was 63 years old through logistic regression. All patients were divided into two cohorts, age <63 and age ≥63-years old; on the basis of renal recovery at 30 days after AKI, the two patient cohorts were further divided into a renal recovery group and a renal nonrecovery group. Multivariate logistic regression was used to analyze the risk factors affecting renal recovery in the two cohorts.
Results
The 30-day renal recovery rate of patients aged <63 years was 70.0% (198/283), multivariate analysis showed that the independent risk factors affecting renal nonrecovery in age <63 years old included AKI stage, blood lactate level and hemoglobin level. The 30-day renal recovery rate of patients aged ≥63 years was 28.7% (86/300), multivariate analysis showed that the independent risk factors for renal nonrecovery in age ≥63-years old included diabetes mellitus, surgery with general anesthesia, AKI stage, APACHE II score, eGFR, and hemoglobin level.
Conclusions
The renal nonrecovery after AKI in critically ill patients in patients aged ≥63 years was more strongly affected by multiple risk factors, such as diabetes mellitus, surgery with general anesthesia, eGFR, and APACHE II score, in addition to hemoglobin and AKI stage.
Acknowledgements
The preprint of this article has been posted on Research Square from 7 April 2022. The link was https://doi.org/10.21203/rs.3.rs-1513159/v1.
Ethical approval
Our protocols were approved by the institutional review boards of Peking University People’s Hospital (approval No. 2019PHB042-01) and performed according to the recommendations of the Declaration of Helsinki for Biomedical Research involving human subjects. The institutional review boards of Peking University People’s Hospital approved to waive of the need for an informed consent and to use the opt-out approach in the study, because the data were retrospectively and anonymously analyzed.
Author contributions
XZ and CL substantially contributed to the conception and design of the study and were major contributors in writing the original manuscript. FZ and SL also substantially contributed to the conception and design of the study and were contributors to the revision of the manuscript. YL, FG, HX, YJ, SL, MC, TD and ZW substantially contributed to the acquisition and analysis of the data. All authors read and approved the final manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s)
Data availability statement
The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.